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Published 12:00 23 Jul 2014 BST
Updated 06:17 18 Dec 2014 GMT
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BFFS - Cameron and Drew have been close friends for years
Fellow presenter Kyle Sandilands added a sour note, however, commenting: "Let's hope she misses out on the Drew Barrymore drug years, because those were a great thing to watch, but not so good to be in, I'd imagine."
Barrymore had a famously troubled upbringing, and best friend Cameron was very quick to jump to her defence.
The actress shot the comment down, saying: "I'm sure, Kyle, you've never been through a drug phase, have you? Or alcoholism or anything like that? Pretty clean… always did it right? Congratulations."
Kyle attempted to smooth over the jibe by bringing up his friendship with Cameron's boyfriend Benji Madden, but the Charlie's Angels star was having none of it and called an end to the interview.
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