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Published 21:30 13 May 2015 BST
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According to The Huffington Post, the pair became firm friends and Ava's mother Christina described her chemotherapy sessions as "like a playdate" due to the bond between the two little girls, adding that she had not been afraid when losing her hair as she had a friend who looked just like her.
Tragically, while Ava is now in remission, Penny has now been told she has just weeks to live.
“They are best friends through tragedy but they found each other and they’re going to hold on to each other for as long as possible,” said Christina.
“Penny got to enjoy having a best friend. Ava got to enjoy that and Penny will forever be in our hearts and we will always remember her.”
Both families are now fundraising, with Ava's parents seeking to cover her medical bills and Penny's parents trying to raise money to allow her father to leave work and spend the next few weeks with the three-year-old. You can find more information here.

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