PICTURE: Police Release E-Fit of New Suspect in Madeline McCann Case

Over six years after she disappeared, British police say they have a "significantly changed" version of events in the case of Madeline McCann.

The Leicestershire child of two doctors, Kate and Gerry McCann, Madeline went missing while the family was holidaying in Portugal in May 2007.

The Portuguese authorities dropped the case in 2008, but a UK review has been ongoing since May 2011.

Over the weekend, Scotland Yard released an e-fit of a man seen in and around Praia de Luz the week of Madeline’s disappearance. This man is now wanted for questioning in relation to the case.

Tonight, a BBC Crimewatch appeal will air on UK television and is set to feature "the most detailed reconstruction" of the case yet. 

According to the BBC, Detective Chief Inspector Andy Redwood, who is heading the investigation, said: "The timeline we have now established has given new significance to sightings and movements of people in and around Praia da Luz at the time of Madeleine's disappearance.

Madeline was three when she went missing in Portugal

"Our work to date has significantly changed the timeline and the accepted version of events that has been in the public domain to date.

"It has allowed us to work with Crimewatch to build the most detailed reconstruction as yet, and highlight very specific appeal points.

"I hope that when the public see our investigative strands drawn together within the overall context of that appeal, it will bring in new information that moves our investigation forward."

The Crimewatch appeal will be shown on BBC One tonight from 9pm.